The human Y chromosome contains very low levels of nucleotide variation. It has been variously hypothesized that this invariance reflects historic reductions in the human male population, a very recent common ancestry, a slow rate of molecular evolution, an inability to evolve adaptively, or frequent selective sweeps acting on genes borne on the Y chromosome. We propose an alternative theory in which human Y chromosome evolution is driven by mutations in the maternally inherited mitochondrial genome, which impair male fertility and (...) ultimately lead to a reduction in the effective population size (Ne) and consequently the variability of the Y chromosome. BioEssays 24:275–279, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10062. (shrink)

Mitochondrial function is achieved through the cooperative interaction of two genomes: one nuclear (nuDNA) and the other mitochondrial (mtDNA). The unusual transmission of mtDNA, predominantly maternal without recombination is predicted to affect the fitness of male offspring. Recent research suggests the strong sexual dimorphism in aging is one such fitness consequence. The uniparental inheritance of mtDNA results in a selection asymmetry; mutations that affect only males will not respond to natural selection, imposing a male‐specific mitochondrial mutation load. Prior work has (...) implicated this male‐specific mutation load in disease and infertility, but new data from fruit flies suggests a prominent role for mtDNA in aging; across many taxa males almost invariably live shorter lives than females. Here we discuss this new work and identify some areas of future research that might now be encouraged to explore what may be the underpinning cause of the strong sexual dimorphism in aging.Editor's suggested further reading in BioEssays: Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations AbstractMitochondrial manoeuvres: Latest insights and hypotheses on mitochondrial partitioning during mitosis in Saccharomyces cerevisiae AbstractMitochondria and the culture of the Borg Abstract. (shrink)

Microsatellites are among the most versatile of genetic markers, being used in an impressive number of biological applications. However, the evolutionary dynamics of these markers remain a source of contention. Almost 20 years after the discovery of these ubiquitous simple sequences, new genomic data are clarifying our understanding of the structure, distribution and variability of microsatellites in genomes, especially for the eukaryotes. While these new data provide a great deal of descriptive information about the nature and abundance of microsatellite sequences (...) within eukaryotic genomes, there have been few attempts to synthesise this information to develop a global concept of evolution. This review provides an up‐to‐date account of the mutational processes, biases and constraints believed to be involved in the evolution of microsatellites, particularly with respect to the creation and degeneration of microsatellites, which we assert may be broadly viewed as a life cycle. In addition, we identify areas of contention that require further research and propose some possible directions for future investigation. BioEssays 28: 1040–1050, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Shors & Matzel's target article is a thought-provoking attempt to reconceptualise long-term potentiation as an attentional or arousal mechanism rather than a memory storage mechanism. This is incompatible with the facts of the neurobiology of attention and of the behavioural neurophysiological properties of hippocampal neurons.

Our only channel of information about the world is the impact of external forces on our sensory surfaces. So says science itself. There is no clairvoyance. How, then, can we have parlayed this meager sensory input into a full-blown scientific theory of the world? This is itself a scientific question. The pursuit of it, with free use of scientific theory, is what I call naturalized epistemology. The Roots of Reference falls within that domain. Its more specific concern, within that domain, (...) is reference to concrete and abstract objects: what such reference consists in, and how we achieve it. (shrink)

That holobionts are units of selection squares poorly with the observation that microbes are often recruited from the environment, not passed down vertically from parent to offspring, as required for collective reproduction. The taxonomic makeup of a holobiont’s microbial community may vary over its lifetime and differ from that of conspecifics. In contrast, biochemical functions of the microbiota and contributions to host biology are more conserved, with taxonomically variable but functionally similar microbes recurring across generations and hosts. To save what (...) is of interest in holobiont thinking, we propose casting metabolic and developmental interaction patterns, rather than the taxa responsible for them, as units of selection. Such units need not directly reproduce or form parent-offspring lineages: their prior existence has created the conditions under which taxa with the genes necessary to carry out their steps have evolved in large numbers. These taxa or genes will reconstruct the original interaction patterns when favorable conditions occur. Interaction patterns will vary in ways that affect the likelihood of and circumstances under which such reconstruction occurs. Thus, they vary in fitness, and evolution by natural selection will occur at this level. It is on the persistence, reconstruction, and spread of such interaction patterns that students of holobiosis should concentrate, we suggest. This model also addresses other multi-species collectively beneficial interactions, such as biofilms or biogeochemical cycles maintaining all life. (shrink)

The third volume of Professor Guthrie's great history of Greek thought, entitled The Fifth-Century Enlightenment, deals in two parts with the Sophists and Socrates, the key figures in the dramatic and fundamental shift of philosophical interest from the physical universe to man. Each of these parts is now available as a paperback with the text, bibliography and indexes amended where necessary so that each part is self-contained. The Sophists assesses the contribution of individuals like Protagoras, Gorgias and Hippias to the (...) extraordinary intellectual and moral fermant in fifth-century Athens. They questioned the bases of morality, religion and organized society itself and the nature of knowledge and language; they initiated a whole series of important and continuing debates, and they provoked Socrates and Plato to a major restatement and defence of traditional values. (shrink)

This book is devoted to the problems of the growth of science. These prob lems, neglected for a long time by the philosophers of science, have become in the 60's and 70's a subject of vivid discussion. There are philosophers who stress only the dependence of science upon various sociological, psycho logical and other factors and deny any internal laws of the development of knowledge, like approaching the truth. The majority rejects such nihilism and searches for the laws of the (...) growth of science. However, they often overlook the role of the Correspondence Principle which connects the suc cessive scientific theories. On the other hand, some authors, while stressing the role of this principle, overlook logical difficulties connected with it, e. g. the problem of the incompatibility of successive theories, of the falsity of some of their assumptions, etc. I believe the Correspondence Principle to be a basic principle of the pro gress of contemporary physics and, probably, of every advanced science. How ever, this principle must be properly interpreted and the above-mentioned logical difficulties must be solved. Their solution requires, as it seems, revealing the idealizational nature of the basic laws of science, in any case of the quantitative laws of advanced sciences. This point has been recently emphasized by some Polish philosophers, especially in Poznan. (shrink)

The pressures that led to the evolution of episodic memory have recently seen much discussion, but a fully satisfactory account of them is still lacking. We seek to make progress in this debate by taking a step backward, identifying four possible ways that episodic memory could evolve in relation to simulationist future planning—a similar and seemingly related ability. After distinguishing each of these possibilities, the paper critically discusses existing accounts of the evolution of episodic memory. It then presents a novel (...) argument in favor of the view that episodic memory is a by-product of the evolution of simulationist future planning. The paper ends by showing that this position allows for the maintenance of the traditional view that episodic memory operates on stored memory traces, as well as explaining a number of key features of episodic memory: its being subject to frequent and systematic errors, its neural co-location with the capacity for simulationist future planning, and the potential existence of non-human episodic memory. (shrink)

Martin Buber is considered one of the 20th centuryes greatest thinkers and his contributions to philosophy, theology and education are testimony to this. His thought is founded on the idea that people are capable of two kinds of relations, namely I-Thou and I-It, emphasising the centrality of dialogue in all spheres of human life. For this reason, Buber is considered by many to be the philosopher of dialogue par excellence. After Buberes death the appreciation of his considerable legacy to the (...) various disciplines in which he had worked became rather muted, but was never completely forgotten. There is now a renewed and growing interest in Buberes thought, especially in his philosophy of education. This book brings together aspects of Buberes philosophy and educational practice, and explains their significance for peace dialogue and for conflict resolution, both between individuals and communities. Buber's philosophy of dialogue and views on education are pivotal in demonstrating the personal and social benefits of dialogical education as well as the dangers of non-dialogical education. The book will be valuable reading for academics, researchers and postgraduate students interested in Martin Buber, education, peace dialogue and conflict resolution. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Lateral gene transfer, the exchange of genetic information between lineages, not only makes construction of a universal Tree of Life difficult to achieve, but calls into question the utility and meaning of any result. Here I review the science of prokaryotic LGT, the philosophy of the TOL as it figured in Darwin’s formulation of the Theory of Evolution, and the politics of the current debate within the discipline over how threats to the TOL should be represented outside it. We could (...) encourage a more realistic and supportive public understanding of evolution by admitting that what we believe in is not a unified meta-theory but a versatile and well-stocked explanatory toolkit. (shrink)

The identification of an informal concept of ‘effective calculability’ with a rigorous mathematical notion like ‘recursiveness’ or ‘Turing computability’ is still viewed as problematic, and I think rightly so. I analyze three different and conflicting perspectives Gödel articulated in the three decades from 1934 to 1964. The significant shifts in Gödel's position underline the difficulties of the methodological issues surrounding the Church-Turing Thesis.

Computationalism holds that our grasp of notions like ‘computable function’ can be used to account for our putative ability to refer to the standard model of arithmetic. Tennenbaum's Theorem has been repeatedly invoked in service of this claim. I will argue that not only do the relevant class of arguments fail, but that the result itself is most naturally understood as having the opposite of a reference-fixing effect — i.e., rather than securing the determinacy of number-theoretic reference, Tennenbaum's Theorem points (...) towards a sense in which portions of our computational vocabulary should be regarded as model-relative. (shrink)

The notion of an algebraic semantics of a deductive system was proposed in [3], and a preliminary study was begun. The focus of [3] was the definition and investigation of algebraizable deductive systems, i.e., the deductive systems that possess an equivalent algebraic semantics. The present paper explores the more general property of possessing an algebraic semantics. While a deductive system can have at most one equivalent algebraic semantics, it may have numerous different algebraic semantics. All of these give rise to (...) an algebraic completeness theorem for the deductive system, but their algebraic properties, unlike those of equivalent algebraic semantics, need not reflect the metalogical properties of the deductive system. Many deductive systems that don't have an equivalent algebraic semantics do possess an algebraic semantics; examples of these phenomena are provided. It is shown that all extensions of a deductive system that possesses an algebraic semantics themselves possess an algebraic semantics. Necessary conditions for the existence of an algebraic semantics are given, and an example of a protoalgebraic deductive system that does not have an algebraic semantics is provided. The mono-unary deductive systems possessing an algebraic semantics are characterized. Finally, weak conditions on a deductive system are formulated that guarantee the existence of an algebraic semantics. These conditions are used to show that various classes of non-algebraizable deductive systems of modal logic, relevance logic and linear logic do possess an algebraic semantics. (shrink)

Concreteness ratings are frequently used in a variety of disciplines to operationalize differences between concrete and abstract words and concepts. However, most ratings studies present items in isolation, thereby overlooking the potential polysemy of words. Consequently, ratings for polysemous words may be conflated, causing a threat to the validity of concreteness‐ratings studies. This is particularly relevant to metaphorical words, which typically describe something abstract in terms of something more concrete. To investigate whether perceived concreteness ratings differ for metaphorical versus non‐metaphorical (...) word meanings, we obtained concreteness ratings for 96 English nouns from 230 participants. Results show that nouns are perceived as less concrete when a metaphorical (versus non‐metaphorical) meaning is triggered. We thus recommend taking metaphoricity into account in future concreteness‐ratings studies to further improve the quality and reliability of such studies, as well as the consistency of the empirical studies that rely on these ratings. (shrink)

Kenneth Goodpaster has criticized ethicists like Feinberg and Frankena for too narrowly circumscribing the range of moral considerability, urging instead that “nothing short of the condition of being alive” is a satisfactory criterion. Goodpaster overlooks at least one crucial objection: that his own “condition of being alive” may aIso be too narrow a criterion of moral considerability, since “being in existence” is at least as plausible and nonarbitrary a criterion as is Goodpaster’s. I show that each of the arguments that (...) Goodpaster musters in support of his criterion can be used equally weIl to bolster “being in existence” as a test of moral considerability. Moreover, I argue that “being in existence” appears to be a stronger criterion overall, since it is broader. Until or unless a fuller justification is forthcoming of “being alive” as a satisfactory criterion of moral considerability-a justification which must demonstrate that “mere things,” included under the condition of “being in existence,” do not deserve moral consideration--Goodpaster’sthesis is confronted with a serious problem. (shrink)

The companion piece to this article, “Situating Moral Justification,” challenges the idea that moral epistemology's mission is to establish a single, all‐purpose reasoning strategy for moral justification because no reasoning practice can be expected to deliver authoritative moral conclusions in all social contexts. The present article argues that rethinking the mission of moral epistemology requires rethinking its method as well. Philosophers cannot learn which reasoning practices are suitable to use in particular contexts exclusively by exploring logical relations among concepts. Instead, (...) in order to understand which reasoning practices are capable of justifying moral claims in different types of contexts, we need to study empirically the relationships between reasoning practices and the contexts in which they are used. The article proposes that philosophers investigate case studies of real‐world moral disputes in which people lack shared cultural assumptions and/or are unequal in social power. It motivates and explains the proposed case study method and illustrates the philosophical value of this method through a case study. (shrink)

The last section of “Lecture at Zilsel’s” [9, §4] contains an interesting but quite condensed discussion of Gentzen’s first version of his consistency proof for P A [8], reformulating it as what has come to be called the no-counterexample interpretation. I will describe Gentzen’s result (in game-theoretic terms), fill in the details (with some corrections) of Godel's reformulation, and discuss the relation between the two proofs.

The work of Professor Jaeger on the Aristotelian metaphysics, and its modification by the late Hans von Arnim, have raised many new points of the greatest interest, and may, I hope, be considered as having opened up a large and fascinating new field for discussion rather than as having closed the matter. It is a subject which must be considered as a whole. There would be little profit in writing short notes on isolated points in the arguments of the two (...) scholars. Anyone who, possessed of some previous acquaintance with the Aristotelian corpus, reads their work is inevitably stimulated to return to Aristotle with his mind full of fresh ideas. If after a re-examination of the texts he feels he has a different story to tell, he must tell it for himself. That is my excuse for an account which must include much which was always known and much which has arisen out of the work of Jaeger and von Arnim. My conclusions are not the same as theirs, and the argument must stand or fall as a consistent whole. (shrink)

Brindley proposed that we initially generate movements , under higher cerebral control. As the movement is practiced, the cerebellum learns to link within itself the context in which the movement is made to the lower level movement generators. Marr and Albus proposed that the linkage is established by a special input from the inferior olive, which plays upon an input-output element within the cerebellum during the period of the learning. When the linkage is complete, the occurrence of the context (represented (...) by a certain input to the cerebellum) will trigger (through the cerebellum) the appropriate motor response. The movement is distinguished from the conscious movement by its now being automatic, rapid, and stereotyped. The idea is still controversial, but has been supported by a variety of animal studies and, as reviewed here, is consistent with the results of a number of human PET and ablation studies. I have added to the idea of context-response linkage what I think is another important variable: novel combinations of downstream elements. With regard to the motor system and the muscles, this could explain how varied combinations of muscles may become active in precise time-amplitude specifications so as to produce coordinated movements appropriate to specific contexts. In this target article, I have further extended this idea to the premotor parts of the brain and their role in cognition. These areas receive influences from the cerebellum; they are active both in planning movements that are to be executed and in thinking about movements that are not to be executed. From recent evidence, the cerebellar output extends even to what has been characterized as the ultimate frontal planning area, the cortex, area 46. The cerebellum thus may be involved in context-response linkage, and response combination even at these higher levels. The implication would be that, through practice, an experiential context would automatically evoke a certain mental action plan. The plan would be in the realm of thought, and could lead to execution. The specific cerebellar contribution would be one of the context linkage and the shaping of the response, through trial and error learning. The prefrontal and premotor areas could still plan without the help of the cerebellum, but not so automatically, rapidly, stereotypically, so precisely linked to context, or so free of error. Nor would their activities improve optimally with mental practice. (shrink)

This paper proposes an ecological approach to the perception and interpretation of signs. The theory draws upon the ecological approach of James Gibson . It is proposed that cultural and natural perception can both be explained in terms of the direct pick-up of structured information and the Gibsonian concept of affordances without having to invoke a sharp distinction between direct and indirect perception. The application of the theory is exemplified through attention to language and to the visual and audio arts.

The genetically-modified-organism (GMO) experience has been prominent in motivating science, industry, and regulatory communities to address the social and ethical dimensions of nanotechnology. However, there are some significant problems with the GMO-nanotech analogy. First, it overstates the likelihood of a GMO-like backlash against nanotechnology. Second, it invites misconceptions about the reasons for public engagement and social and ethical issues research as well as their appropriate roles in nanotech research, development, application, commercialization, and regulatory processes. After an explication of the standard (...) GMO-Nanotech analogy, these two problems are discussed in turn. (shrink)

Even lawyers who obey the law often seem to act unethically--interfering with the discovery of truth, subverting justice, and inflicting harm on innocent people. Standard arguments within legal ethics attempt to show why it is permissible to do something as a lawyer that it would be wrong to do as an ordinary person. But in the view of most critics these arguments fail to turn wrongs into rights. Even many lawyers think legal ethics is flawed because it does not accurately (...) describe the considerable moral value of their work. In Lawyers and Fidelity to Law, Bradley Wendel introduces a new conception of legal ethics that addresses the concerns of lawyers and their critics alike.Wendel proposes an ethics grounded on the political value of law as a collective achievement that settles intractable conflicts, allowing people who disagree profoundly to live together in a peaceful, stable society. Lawyers must be loyal and competent client representatives, Wendel argues, but these obligations must always be exercised within the law that constitutes their own roles and confers rights and duties upon their clients. Lawyers act unethically when they treat the law as an inconvenient obstacle to be worked around and when they twist and distort it to help their clients do what they are not legally entitled to do. Lawyers and Fidelity to Law challenges lawyers and their critics to reconsider the nature and value of ethical representation. (shrink)

Humans are standouts in their propensity to trade. More specially, the kind of trading found in humans—featuring the exchange of many different goods and services with many different others, for the mutual benefit of all the involved parties—far exceeds anything that is found in any other creature. However, a number of important questions about this propensity remain open. First, it is not clear exactly what makes this propensity so different in the human case from that of other animals. Second, it (...) is not clear why other animals did not acquire this propensity to the extent that humans did. Third, it is not clear what explains the fact that the extent to which humans engage in trade is culturally highly variable. The paper argues that at the heart of the human-animal divergence in this propensity is the particular socio-cultural environment in which humans evolved. This has led them to sometimes, but not always, acquire the cognitive technology (writing, algebra, tallying devices, money, etc.) to support a sophisticated disposition and capacity for reciprocal cooperation, and deep and wide concepts of property and exchange value. (shrink)

Engineering Ethics: Challenges and Opportunities aims to set a new agenda for the engineering profession by developing a key challenge: can the great technical innovation of engineering be matched by a corresponding innovation in the acceptance and expression of ethical responsibility? Central features of this stimulating text include: · An analysis of engineering as a technical and ethical practice providing great opportunities for promoting the wellbeing and agency of individuals and communities. · Elucidation of the ethical opportunities of engineering in (...) three key areas: Engineering for Peace, emphasising practical amelioration of the root causes of conflict rather than military solutions. Engineering for Health, focusing on close collaboration with healthcare professionals for both the promotion and restoration of health. Engineering for Development, providing effective solutions for the reduction of extreme poverty. · Innovative strategies for implementing these ethical opportunities are described: Emphasis on the personal responsibility of every engineer and on the benefits of supporting social structures. Use of language and concepts that are appealing to business managers and political decision makers. · Future prospects for increasing the acceptance and expression of ethical responsibility by engineers are envisaged. · Engineering Ethics: Challenges and Opportunities provides engineers, decision makers and the wider public with new understanding of the potential of engineering for the promotion of human flourishing. (shrink)

Heidegger affirmed traditional technology, but was opposed to science-based modern technology, in which everything (including man) is considered to be a mere “resource”. This opposition was expressed in the form of deep questioning and a suspicion of superficial evaluation, because the true nature of things was often concealed, though disclosed at times. Ways in which engineers should question technology are proposed, highlighting some of the hazards and injustices associated with technology and also its subtle sociological and psychological influences. The demands (...) of engineering ethics and the use of metaphor in design are other ways in which a narrowly rationalistic technological outlook can be confronted. (shrink)

Neutral monist, panpsychist, naturalist, and phenomenological interpretations of James's theory of mind are canvassed. Culling the true tenets from each, I make a case for a reconciling view on the basis of a distinction between mental and proto-mental properties. The resulting interpretation is compared to two forms of panpsychism identified by T Nagel in his essay of that name.

The veiled recession frame has served several times in the literature to provide examples of modal logics failing to have certain desirable properties. Makinson [4] was the first to use it in his presentation of a modal logic without the finite model property. Thomason [5] constructed a (rather complicated) logic whose Kripke frames have an accessibility relation which is reflexive and transitive, but which is satisfied by the (non-transitive) veiled recession frame, and hence incomplete. In Van Benthem [2] the frame (...) was an essential tool to find simple examples of incomplete logics, axiomatized by a formula in two proposition letters of degree 2, or by a formula in one proposition letter of degree 4 (the degree of a modal formula is the maximal number of nested occurrences of the necessity operator in ). In [3] we showed that the modal logic determined by the veiled recession frame is incomplete, and besides that, is an immediate predecessor of classical logic (or, more precisely, the modal logic axiomatized by the formula pp), and hence is a logic, maximal among the incomplete ones. Considering the importance of the modal logic determined by the veiled recession frame, it seems worthwhile to ask for an axiomatization, and in particular, to answer the question if it is finitely axiomatizable. In the present paper we find a finite axiomatization of the logic, and in fact, a rather simple one consisting of formulas in at most two proposition letters and of degree at most three. (shrink)

This book investigates the architecture of the language faculty by considering what the properties of language reveal about the mental abilities and processes involved in language acquisition. The language faculty, the author argues, must be able not only to accommodate what is general, exceptionless, and universal in language, but must also be capable of dealing with what is irregular, exceptional, and idiosyncratic. In Syntactic Nuts Peter Culicover shows that this is true not only of the lexicon, but for syntax. Marginal (...) and exceptional cases, where there is no straightforward form-meaning correspondence, are dealt with by the language faculty easily and precisely as the general cases. In considering how and why this should be the author argues against the prevailing trend in generative grammar, which takes the learner as either incorporating maximally global generalisations as part of its innate capacity for language, or projecting global generalisations from a very limited input on the basis of innate mechanisms. He suggests that the learning mechanism does not generalize significantly beyond the evidence presented to it, and further that it seeks to form generalizations based on all and only the evidence presented to it. Syntactic Nuts makes a fundamental contribution to generative grammar and syntactic theory. It situates syntactic theory within cognitive science in a novel way. It contributes to an alternative, and yet in many ways traditional, perspective on the manner in which knowledge is represented and processed in the mind. (shrink)

Theists typically think it appropriate to pray to God in the hope that He will thereby intervene in affairs. On the other hand, such prayer is often held to be quite inappropriate for pantheists; a view endorsed by many pantheists themselves. This paper argues for the exact opposite of these positions. It is maintained not only that pantheism can make sense of petitionary prayer but that, despite initial appearances to the contrary, classical theism can not.

The sequence from ideal state to tyran I ny contained in Books VIII-IX of the Republic constitutes neither history nor philosophy of history, but rather completes Plato's overall theory of politics, dealing, like every theoretical science, with simplified or pure cases, and narrated purely for dramatic effort. Popper's view that Plato was fundamentally an historicist is incorrect. Plato makes no straightforward comments on philosophy of history. Perhaps, like many Greeks, he surveyed history pessimistically, but he did not propound an iron (...) law of decay. As a social scientist Plato held that there are laws of political change without supposing the course of history is unalterably fixed. (shrink)

In higher education, interdisciplinarity involves the design of subjects that offer the opportunity to experience ‘different ways of knowing’ from students’ core or preferred disciplines. Such an education is increasingly important in a global knowledge economy. Many universities have begun to introduce interdisciplinary studies or subjects to meet this perceived need. This chapter explores some of the issues inherent in moves towards interdisciplinary higher education. Definitional issues associated with the term ‘academic discipline’, as well as other terms, including ‘multidisciplinary’, ‘cross-disciplinary’, (...) ‘pluridisciplinarity’, ‘transdisciplinarity’ and ‘interdisciplinary’ are examined. A new nomenclature is introduced to assist in clarifying the subtle distinctions between the various positions. The chapter also outlines some of the pedagogical and epistemological considerations which are involved in any move from a conventional form of educational delivery to an interdisciplinary higher education, and recommends caution in any implementation of an interdisciplinary curriculum. (shrink)

Smarandache in 2019 has generalized the algebraic structures to NeutroAlgebraic structures and AntiAlgebraic structures. In this paper, authors, for the first time, define the NeutroAlgebra of neutrosophic triplets group under usual+ and x, built using {Zn, x}, n a composite number, 5 < n < oo, which are not partial algebras. As idempotents in Zn alone are neutrals that contribute to neutrosophic triplets groups, we analyze them and build NeutroAlgebra of idempotents under usual + and x, which are not partial (...) algebras. We prove in this paper the existence theorem for NeutroAlgebra of neutrosophic triplet groups. This proves the neutrals assocaited with neutrosophic triplet groups in { Zn, X} under product is a NeutroAlgebra of triplets. We also prove the non-existence theorem of NeutroAlgebra for neutrosophic triplets in case of Zn when n = 2p, 3p and 4p (for some primes p). Several open problems are proposed. Further, the NeutroAlgebras of extended neutrosophic triplet groups have been obtained. (shrink)

Haeckels theory of recapitulation shall be extended by the following rule: During the ontogenetical recapitulation of the phenotypical effects, the recapitulation of the phylogenetical natural selection factors according to the genotypical potentials is a condition of manifestation. The phylogenetical natural selectionfactor produces the activation of the gen as ontogenetical manifestation-stimulus. Factor of natural selection is the one of the extern or intern environment to which has happened the adaption in the phylogenesis. Concerning the intern environments the phenotypical effect of the (...) preliminary phase of development is not only the phylogenetical factor of natural selection according to the genotypical potential of the following phase of development, but also the ontogenetical stimulus of manifestation for the phenotypical effect of the following phase of development. Phenotypical effects can present themselves as stimulus-dependencial modifications, which are bound to the manifestation-stimulus and cease after its disappearence. They can also present themselves as stimulus-independencial lasting modifications, which become independent from the manifestation-stimulus and remain preserved after its ceasing, because the gen once activated by the stimulus reproduces itself in the state of being activated and is so transmitted during the multiplication of cells from cell to cell and during the multiplication of organisms from generation to generation. This view gives new chances for interpretating causal connections of the phylogenetical evolution and involution as well as new possibilities for an explanation of evolutionary mechanism of maturation and of involutionary mechanism of ageing in the ontogenesis and also the occuring appearences of acceleration and retardation.DieHaeckel'sche Rekapitulationstheorie wird durch die folgende Rekapitulationsregel erweitert: Bei der ontogenetischen Rekapitulation der erscheinungsbildlichen Leistungen ist die Rekapitulation der phylogenetischen Auslesefaktoren der entsprechenden erbildlichen Fähigkeiten Manifestationsbedingung. Der phylogenetische Auslesefaktor bewirkt als ontogenetischer Manifestationsreiz die Genaktivierung. Auslesefaktor ist derjenige Faktor der äusseren oder inneren Umwelt, an den in der Phylogenese die Anpassung erfolgt ist. Im Bereich der inneren Umwelt ist daher die erscheinungsbildliche Leistung der vorhergehenden Entwicklungsstufe sowohl der phylogenetische Auslesefaktor für die erbbildliche Fähigkeit der nachfolgenden Entwicklungsstufe als auch der ontogenetische Manifestationsreiz für die erscheinungsbildliche Leistung der nachfolgenden Entwicklungsstufe. Die erscheinungsbildlichen Leistungen können als reizabhängige Modifikation auftreten, die also vom Manifestationsreiz abhängig bleibt und nach seinem Aufhören auch wieder verschwindet, sie können aber auch als reizunabhängige Dauermodifikation auftreten, die also vom Manifestationsreiz unabhängig wird und nach seinem Aufhören erhalten bleibt, weil das durch den Reiz einmal aktivierte Gen sich im Status des Aktiviertseins bei der Zellvermehrung von Zelle zu Zelle und bei der Vermehrung der Organismen von Generation zu Generation fortpflanzt. Damit ergeben sich neue Möglichkeiten einer Deutung der Kausalzusammenhänge bei der phylogenetischen Evolution und Involution, sowie neue Ansätze einer Erklärung des Evolutionsmechanismus der Reifung und des Involutionsmechanismus des Alterns in der Ontogenese, sowie der dabei auftretenden Erscheinungen der Acceleration und der Retardation. (shrink)

Results of surveys in which pharmacy students and pharmacists responded to ethical dilemmas are discussed. Respondents indicated a high level of concern about patient welfare and patient rights in dilemmas involving conflicts with socio-economic issues, and with peers and physicians. Conflicts that might arise as the roles of pharmacists change and the health-care systems evolve are also discussed.

There are many difficulties connected with the notion of punishment, but perhaps it is not disputed that it is at least a deliberate infliction of pain of one kind or another. Of course, that is not an adequate description of its nature, but so far as it goes it seems to be a true one.1 And the idea that it could be morally right deliberately tp inflict pain on another, unlike, for example, the idea that it is morally right to (...) tell the truth, is so manifestly intolerable unless we look beyond the infliction of pain itself that we are tempted to leap forward to the question, “What is the justification of such action?” before making quite explicit to ourselves what it is, over and above its being the deliberate infliction of pain, that constitutes the action punishment at all. The questions “Why hurt?” and “Why punish?” are confused with one another. No doubt some distinction between them is present vaguely in everyone's mind and the confusion may not be in fact serious: but anyhow it is a defect and should be remedied. (shrink)

To translate is one thing; to say how we do it, is another. The practice is familiar enough, and there are familiar theories of it. But when we try to look more closely, theory tends to obscure rather than explain, and the familiar practice—an ancient practice, without which Western civilisation is unthinkable—appears to be just baffling, its very possibility a mystery.

Readers of the Journal may know little of Melchior Palágyi. Even on the Continent his work has been very inadequately recognized. It is not that he has written little: he published some books and many articles during his lifetime, in German as well as in Magyar, and since his death, Barth of Leipzig has issued an edition of his selected works, including his most important contribution, Naturphilosophische Vorlesungen, also the Wahrnehmungslehre and Zur Weltmechanik. He has many enthusiastic admirers, and those (...) who care to look up the Preussische Jahrbücher, March 1926, will find there a most informative and highly appreciative article on his general philosophy by Werner Deubel, who in the same journal, some two years previously, discussed the work of a kindred spirit, Ludwig Klages. It was Deubel's article that first roused my interest in Palágyi and led me to study his more important writings. (shrink)

Everyone knows the statement of Servius that Virgil was compelled by Augustus to alter the second half of the Fourth Georgic after the fall of Gallus, and that he substituted the story of Aristaeus for the laudes Galli. This statement, often doubted by older generations, has had such a remarkable success in recent years that anyone who ventures to impugn it must feel that he is pleading with a halter round his neck before a one-sided jury. It is notable, however, (...) that these jurors, though one-sided, are by no means united, save in their determination to uphold the credit of Servius. One group will assure us that the episode of Aristaeus shows obvious signs not only of haste but of immaturity, and they draw a pathetic picture of the grief-stricken Virgil, ordered to bring out a second edition minus the praises of his friend Gallus, and half-heartedly throwing together some bits of juvenile stuff which he happened to have handy. Others assure us that the tale of Aristaeus shows us a more mature Virgil, nearer to the Virgil of the Aeneid. But the Servians really cannot have it both ways. They must make up their minds in the one direction or in the other if they are to be taken seriously. They make it doubly difficult for us to take them seriously when they try to tell us what Servius meant—but of that more anon. The present paper is an attempt by a converted Servian to examine frankly the arguments which have been advanced in support of Servius. Most of these may be found in Skutsch, Aus Vergils Frühzeit, pp. 140–147. One is very reluctant to use disparaging words about an eminent scholar who has served the cause of learning in so many ways; but it can scarcely be denied that the work just mentioned, in spite of its ingenuity and enthusiasm, shows a lamentable lack of three great essentials—a judicial temper, accurate statement of facts, and cogent reasoning. There is also at times a regrettable vagueness of expression, suggesting that the author is concealing inward doubts or shrinking from thought. All these deficiencies are to some extent present in the section with which this paper is concerned. (shrink)

This paper is about the work of a long forgotten philosopher and his views which have surprising relevance to discussions in present-day philosophy of mind and cognitive science. I argue that, far from being a traditional idealist, Mitchell advanced a very subtle position best seen as marking a transition from idealist views and later materialist accounts, the latter popularly attributed to Australian philosophers in the second half of the 20th century.

In this new post-genomic age of medicine and biomedical technology, there will be novel approaches to understanding disease, and to finding drugs and cures for diseases. Hundreds of new “disease genes” thought to be the causative agents of various genetic maladies will be identified and added to the list of hundreds of such genes already identified. Based on this knowledge, many new genetic tests will be developed and used in genetic screening programs. Genetic screening is the foundation upon which reproductive (...) technologies such as pre-natal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are based. Genetic information arising from the human genome may also be used in attempts to redesign the human genetic inheritance by engineering the human germline (germline engineering). In each of these technologies—PND, PGD, and germline engineering—there are serious ethical and social concerns. Moreover, all three are eugenic in nature because they strive to control which genes are passed down to future generations. The goals of this article are threefold: 1) to introduce the science behind the three technologies; 2) to give a brief overview of eugenics in the past century and show how these genetic technologies are eugenic; and 3) to present a vision of social justice that rejects the genetic determinism upon which eugenics is based and embraces a holistic, ecological view of nature and humanity. (shrink)

In the last two decades we have witnessed considerable efforts directed towards making electronic healthcare records comparable and interoperable through advances in record architectures and (bio)medical terminologies and coding systems. Deep semantic issues in general, and ontology in particular, have received some interest from the research communities. However, with the exception of work on so-called ‘controlled vocabularies’, ontology has thus far played little role in work on standardization. The prime focus has been rather the rapid population of terminologies at the (...) level of fine detail. In this paper, we argue that more efforts are needed on the side of both research and standardization to ensure that the coding systems used in electronic healthcare records enjoy a semantics that is coherent with the semantics of the record. We propose realist ontology as a method to bring about this coherence by means of a robust system of top-level ontological categories. (shrink)

The purpose of this article is to show a structural relationship in Dutch between sentences with the main verb "duren" (last) and specifying complements such as een week (a week) or "drie kwartier" (three quarters of an hour) on the one hand, and sentences with Duration Measuring Adverbials such as "gedurende een week" (for a week), "gedurende die week" (lit: for that week) on the other.

During the early years of the COVID-19 pandemic, preclinical and clinical research were sped up and scaled up in both the public and private sectors and in partnerships between them. This resulted in some extraordinary advances, but it also raised a range of issues regarding the ethics, rigour, and integrity of scientific research, academic publication, and public communication. Many of the failures of scientific rigour and integrity that occurred during the pandemic were exacerbated by the rush to generate, disseminate, and (...) implement research findings, which not only created opportunities for unscrupulous actors but also compromised the methodological, peer review, and advisory processes that would usually identify sub-standard research and prevent compromised clinical or policy-level decisions. While it would be tempting to attribute these failures of science and its translation solely to the “unprecedented” circumstances of the COVID-19 pandemic, the reality is that they preceded the pandemic and will continue to arise once it is over. Existing strategies for promoting scientific rigour and integrity need to be made more rigorous, better integrated into research training and institutional cultures, and made more sophisticated. They might also need to be modified or supplemented with other strategies that are fit for purpose not only in public health emergencies but in any research that is sped-up and scaled up to address urgent unmet medical needs. (shrink)

Recent perspectives on corporate social responsibility have called for increased research on how CSR affects individuals. Research is needed to examine whether individual differences affect the relationship between CSR and individual reactions to CSR. In response, this experimental study examined how perceptions of corporate citizenship influence job applicant attraction and work role definitions. Personal values and education concerning CSR are considered as interactive factors affecting the influence of perceptions of corporate citizenship. Results indicate that perceived corporate citizenship had a greater (...) impact on job applicant attraction for those individuals who received prior education regarding CSR and for those who were higher in other-regarding value orientation. Furthermore, perceived corporate citizenship had a positive impact on the extent to which participants defined CSR as a personal work role responsibility. The authors also discuss the practical implications of these results for job applicant attraction and employee socialization. (shrink)

Published here in paperback for the first time is much of a final and long-anticipated work by R. G. Collingwood on philosophy of history, of which subject he was the greatest exponent in the English language. The original text of this work was only recently discovered. It is accompanied by shorter unpublished writings by Collingwood on historical knowledge and inquiry. A lengthy editorial introduction sets these writings in their context, and discusses philosophical questions to which they give rise.